Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-1,3-dimethyl-4-[4-(trifluoromethyl)phenyl]-
BQU57
CAS: 1637739-82-2
Molecular Formula: C16H13F3N4O
Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-1,3-dimethyl-4-[4-(trifluoromethyl)phenyl]- - Names and Identifiers
Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-1,3-dimethyl-4-[4-(trifluoromethyl)phenyl]- - Physico-chemical Properties
| Molecular Formula | C16H13F3N4O |
| Molar Mass | 334.3 |
| Density | 1.43±0.1 g/cm3(Predicted) |
| Boling Point | 493.4±45.0 °C(Predicted) |
| Solubility | DMSO: ≥ 36 mg/mL |
| pKa | 2.92±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | In the H2122 and H358 cell lines, BQU57 inhibited RalA and RalB activation, resulting in cell growth inhibition. |
| In vivo study | In mice bearing human lung H2122 tumors, BQU57 (50 mg/kg, I. p.) significantly inhibited the activation of RalA and RalB and caused dose-dependent tumor growth inhibition. |
Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-1,3-dimethyl-4-[4-(trifluoromethyl)phenyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.991 ml | 14.957 ml | 29.914 ml |
| 5 mM | 0.598 ml | 2.991 ml | 5.983 ml |
| 10 mM | 0.299 ml | 1.496 ml | 2.991 ml |
| 5 mM | 0.06 ml | 0.299 ml | 0.598 ml |
Last Update：2024-01-02 23:10:35
Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-1,3-dimethyl-4-[4-(trifluoromethyl)phenyl]- - Reference Information
| biological activity | BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to GTPases Ras and RhoA. |
| target | TargetValue GTPase Ral () |
| Target | Value |
| in vitro study | in H2122 and H358 cell lines, BQU57 inhibits the activation of RalA and RalB, thus causing cell growth inhibition. |
| in vivo study | in mice loaded with human lung H2122 tumors, BQU57 (50 mg/kg, I. p.) significantly inhibited the activation of RalA and RalB and caused dose-dependent tumor growth inhibition. |
Last Update：2024-04-09 21:04:16
![Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-1,3-dimethyl-4-[4-(trifluoromethyl)phenyl]-](http://res.chembk.com/assets/images/structure/HY-12875.gif)
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Spot supply
Product Name: BQU57 Visit Supplier Webpage Request for quotationCAS: 1637739-82-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-1,3-dimethyl-4-[4-(trifluoromethyl)phenyl]-
AMyloid b-Protein (38-40)
AMyloid b-Protein (38-40)